DNA repair is limiting for haematopoietic stem cells during ageing

Anastasia Nijnik, Lisa Woodbine, Caterina Marchetti, +13

Nature

MedicineGeneticsAdult Stem CellStem Cell TransplantationCell Replacement Therapy +3

Nbs1 is required for ATR‐dependent phosphorylation events

Tom Stiff, Caroline Reis, Gemma Alderton, +3

The EMBO Journal

PRKDC mutations in a SCID patient with profound neurological abnormalities

Lisa Woodbine, Jessica A. Neal, Nanda Kumar Sasi, +8

Journal of Clinical Investigation

Creutzfeldt-jakob DiseaseNeurological DisorderGeneticsPathologyDisease Gene Identification +15

Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK

Silvia Costantini, Lisa Woodbine, Lucia Andreoli, +2

DNA repair

ChromatinNucleic Acid ChemistryMolecular RegulationNatural SciencesGenetics +6

Sensitization to Radiation and Alkylating Agents by Inhibitors of Poly(ADP-ribose) Polymerase Is Enhanced in Cells Deficient in DNA Double-Strand Break Repair

Dana A. Löser, Atsushi Shibata, A. Shibata, +3

Molecular Cancer Therapeutics

Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair

Lisa Woodbine, Holly Brunton, Aaron A. Goodarzi, +2

Nucleic Acids Research

XLF-Cernunnos promotes DNA ligase IV–XRCC4 re-adenylation following ligation

Enriqueta Riballo, Lisa Woodbine, Thomas Stiff, +3

Nucleic Acids Research

XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency

Chaowan Guo, Yuka Nakazawa, Lisa Woodbine, +13

Journal of Allergy and Clinical Immunology

Primary ImmunodeficiencyAutoimmune DiseaseImmunodeficienciesImmunologyPathology +9

Accelerated Telomere Shortening and Telomere Abnormalities in Radiosensitive Cell Lines

Erik Cabuy, C. Newton, Gordana Joksiċ, +4

Radiation Research

3D Printed Calcium Phosphate Cement (CPC) Scaffolds for Anti-Cancer Drug Delivery

Yan Wu, Lisa Woodbine, Antony M. Carr, +3

Pharmaceutics

Materials ScienceNanomedicineTissue EngineeringSynthetic Bone SubstituteEngineering +12