ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation

Tom Stiff, Mark O’Driscoll, Nicole Rief, +3

Cancer Research

Checkpoint ResponseDna DamageDna-pk Function RedundantlyRadiation EffectRadiation Exposure +17

Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling

Elen Griffith, Sarah Walker, Carol-Anne Martin, +10

Nature Genetics

Genome InstabilityMolecular PhysiologyGenetic DisorderGeneticsMolecular Biology +3

Chromosome breakage after G2 checkpoint release

Dorothee Deckbar, Julie Birraux, Andrea Krempler, +6

The Journal of Cell Biology

Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome

Louise S. Bicknell, Sarah Walker, Anna Klingseisen, +12

Nature Genetics

Origin Recognition ComplexMeier-gorlin SyndromeDevelopmental BiologySomatic VariantGenetic Disorder +6

Nbs1 is required for ATR‐dependent phosphorylation events

Tom Stiff, Caroline Reis, Gemma Alderton, +3

The EMBO Journal

Identification of the First ATRIP–Deficient Patient and Novel Mutations in ATR Define a Clinical Spectrum for ATR–ATRIP Seckel Syndrome

Tomoo Ogi, Sarah Walker, Tom Stiff, +15

PLoS Genetics

Deficiency in Origin Licensing Proteins Impairs Cilia Formation: Implications for the Aetiology of Meier-Gorlin Syndrome

Tom Stiff, Meryem Alagöz, Diana Alcantara, +5

PLoS Genetics

Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis

Alexander JR Booth, Zuojun Yue, John K. Eykelenboom, +4

eLife

Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1

Tom Stiff, Karen Cerosaletti, Patrick Concannon, +2

Human Molecular Genetics

Prophase-Specific Perinuclear Actin Coordinates Centrosome Separation and Positioning to Ensure Accurate Chromosome Segregation

Tom Stiff, Fabio Echegaray Iturra, Harry Pink, +3

Cell Reports

ChromatinMolecular BiologyChromosome BiologyNuclear OrganizationCytoskeleton +4