Concepedia

A Physiologically Based Pharmacokinetic Analysis of Capecitabine, a Triple Prodrug of 5-FU, in Humans: The Mechanism for Tumor-Selective Accumulation of 5-FU

Yuko Tsukamoto, Yukio Kato, Masako Ura, Ikuo Horii, Hideo Ishitsuka, Hiroyuki Kusuhara, Yuichi Sugiyama

Pharmaceutical Research · 2001 · 85 citations · 28 references

DOI

Concepts

References

28

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

Peter Vaupel, F. Kallinowski, Paul Okunieff · PubMed · 1989 · 3.4K citations

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Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue

Masanori Miwa, Masako Ura, M Nishida et al. · European Journal of Cancer · 1998 · 1.2K citations

, , +12

Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients

Johannes Sch�ller, Jim Cassidy, Étienne Dumont et al. · Cancer Chemotherapy and Pharmacology · 2000 · 666 citations

, , +14

Methotrexate Pharmacokinetics

Kenneth B. Bischoff, Robert L. Dedrick, Daniel S. Zaharko et al. · Journal of Pharmaceutical Sciences · 1971 · 479 citations · Full text

Animal scale-up

Robert L. Dedrick · Journal of Pharmacokinetics and Biopharmaceutics · 1973 · 394 citations