Concepedia

Novel hypomorphic mutation in IKBKG impairs NEMO-ubiquitylation causing ectodermal dysplasia, immunodeficiency, incontinentia pigmenti, and immune thrombocytopenic purpura

Noé Ramirez‐Alejo, Julio César Alcántara‐Montiel, Marco Antonio Yamazaki‐Nakashimada, Carola Durán‐McKinster, Paola Carolina Valenzuela Leon, Francisco Rivas‐Larrauri, Leticia Cedillo‐Barrón, Rosaura Hernández‐Rivas, Leopoldo Santos‐Argumedo

Clinical Immunology · 2015 · 14 citations · 21 references

DOI

Concepts

References

21

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Chen Wang, Li Deng, Mei Hong et al. · Nature · 2001 · 2.1K citations

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Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain

Li Deng, Chen Wang, Erika Spencer et al. · Cell · 2000 · 1.9K citations · Full text

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Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO

Chee-Kwee Ea, Li Deng, Zong-Ping Xia et al. · Molecular Cell · 2006 · 981 citations · Full text

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IKK-γ is an essential regulatory subunit of the IκB kinase complex

David M. Rothwarf, Ebrahim Zandi, Gioacchino Natoli et al. · Nature · 1998 · 959 citations

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TAB2 and TAB3 Activate the NF-κB Pathway through Binding to Polyubiquitin Chains

Atsuhiro Kanayama, Rashu B. Seth, Lijun Sun et al. · Molecular Cell · 2004 · 869 citations · Full text

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