Concepedia

Design, synthesis and preliminary bioactivity evaluations of substituted quinoline hydroxamic acid derivatives as novel histone deacetylase (HDAC) inhibitors

Lei Wang, Xuben Hou, Huansheng Fu, Xiaole Pan, Wenfang Xu, Weiping Tang, Hao Fang

Bioorganic & Medicinal Chemistry · 2015 · 45 citations · 13 references

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References

13

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

Kyle V. Butler, Jay H. Kalin, Camille Brochier et al. · Journal of the American Chemical Society · 2010 · 772 citations · Full text

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Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors

Lewis Whitehead, Markus Dobler, Branko Radetich et al. · Bioorganic & Medicinal Chemistry · 2011 · 156 citations · Full text

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How to Improve Docking Accuracy of AutoDock4.2: A Case Study Using Different Electrostatic Potentials

Xuben Hou, Jintong Du, Jian Zhang et al. · Journal of Chemical Information and Modeling · 2012 · 132 citations

, , +12

Development of Tetrahydroisoquinoline-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities

Yingjie Zhang, Jinhong Feng, Yuping Jia et al. · Journal of Medicinal Chemistry · 2011 · 86 citations · Full text

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Discovery of 2-(6-{[(6-Fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-<i>N</i>-hydroxypyrimidine-5-carboxamide (CHR-3996), a Class I Selective Orally Active Histone Deacetylase Inhibitor

David Moffat, Sanjay R. Patel, Francesca A. Day et al. · Journal of Medicinal Chemistry · 2010 · 83 citations · Full text

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