Lewis Whitehead

Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors

Lewis Whitehead, Markus Dobler, Branko Radetich et al. · Bioorganic & Medicinal Chemistry · 2011 · 153 citations · Full text

Biochemistry, Natural Sciences, Medicine +7

Discovery of LFF571: An Investigational Agent for <i>Clostridium difficile</i> Infection

Matthew J. LaMarche, Jennifer A. Leeds, Adam Amaral et al. · Journal of Medicinal Chemistry · 2012 · 116 citations

Bioorganic Chemistry, Bacteriophage, Investigational Agent +20

Small Molecule-facilitated Degradation of ANO1 Protein

Anke Bill, Michelle Lynn Hall, Jason Borawski et al. · Journal of Biological Chemistry · 2014 · 83 citations · Full text

Protein Chemistry, Protein Function, Biochemistry +5

Optimization of the in Vitro Cardiac Safety of Hydroxamate-Based Histone Deacetylase Inhibitors

Michael D. Shultz, Xueying Cao, Christine Chen et al. · Journal of Medicinal Chemistry · 2011 · 63 citations · Full text

Many Hdac Inhibitors, Cardiovascular Toxicity, Medicinal Chemistry +15

An investigation into pharmaceutically relevant mutagenicity data and the influence on Ames predictive potential

Patrick McCarren, Clayton Springer, Lewis Whitehead · Journal of Cheminformatics · 2011 · 60 citations · Full text