Exposure-dependent incorporation of trifluridine into DNA of tumors and white blood cells in tumor-bearing mouse

TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial

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Evaluation of role of G-CSF in the production, survival, and release of neutrophils from bone marrow into circulation

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Life Sciences, Hematology, Immunology +10

Structure and activity of specific inhibitors of thymidine phosphorylase to potentiate the function of antitumor 2′-deoxyribonucleosides

Masakazu Fukushima, Norihiko Suzuki, Tomohiro Emura et al. · Biochemical Pharmacology · 2000 · 237 citations

Life Sciences, Biochemistry, Oncology +14

Repeated oral dosing of TAS-102 confers high trifluridine incorporation into DNA and sustained antitumor activity in mouse models

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Medicine, Oncology, Pharmacology +13

A novel combination antimetabolite, TAS-102, exhibits antitumor activity in FU-resistant human cancer cells through a mechanism involving FTD incorporation in DNA

Tomohiro Emura, Norihiko Suzuki, Masahiro Yamaguchi et al. · International Journal of Oncology · 2004 · 119 citations

Medicine, Oncology, Pharmacology +14