Structure and activity of specific inhibitors of thymidine phosphorylase to potentiate the function of antitumor 2′-deoxyribonucleosides

Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis.

Michele Relf, S LeJeune, Prudence A. E. Scott et al. · PubMed · 1997 · 834 citations

Medicine, Cancer Biology, Oncology +12

Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor

Fuyuki Ishikawa, Kohei Miyazono, Ulf Hellman et al. · Nature · 1989 · 716 citations

Life Sciences, Hematology, Cell Signaling +10

Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats.

Tetsuhiko Shirasaka, Yuji Shimamoto, Masakazu Fukushima · PubMed · 1993 · 350 citations

Medicine, Pharmacology, Toxicology +11

Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts.

Kunihiko Tatsumi, Masakazu Fukushima, Tetsuhiko Shirasaka et al. · PubMed · 1987 · 261 citations

Life Sciences, Biochemistry, Pharmacology +10

Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity

Kensuke Usuki, Jan Saras, Johannes Waltenberger et al. · Biochemical and Biophysical Research Communications · 1992 · 200 citations

Life Sciences, Cell Biology, Molecular Biology +11