Masakazu Fukushima

Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators

Tetsuhiko Shirasaka, Yuji Shimamato, Hideyuki Ohshimo et al. · Anti-Cancer Drugs · 1996 · 824 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats.

Tetsuhiko Shirasaka, Yuji Shimamoto, Masakazu Fukushima · PubMed · 1993 · 350 citations

Medicine, Pharmacology, Toxicology +11

Inhibitory effects of pyrimidine, barbituric acid and pyridine derivatives on 5-fluorouracil degradation in rat liver extracts.

Kunihiko Tatsumi, Masakazu Fukushima, Tetsuhiko Shirasaka et al. · PubMed · 1987 · 261 citations

Life Sciences, Biochemistry, Pharmacology +10

Structure and activity of specific inhibitors of thymidine phosphorylase to potentiate the function of antitumor 2′-deoxyribonucleosides

Masakazu Fukushima, Norihiko Suzuki, Tomohiro Emura et al. · Biochemical Pharmacology · 2000 · 237 citations

Life Sciences, Biochemistry, Oncology +14

The effect of a thymidine phosphorylase inhibitor on angiogenesis and apoptosis in tumors.

Shigeto Matsushita, Takao Nitanda, Tatsuhiko Furukawa et al. · PubMed · 1999 · 209 citations

Medicine, Oncology, Pharmacology +12