1996 · 291 citations · 104 references
Life SciencesGeneticsMolecular GeneticsMolecular VirologyPharmacogeneticsVirologyAntiretroviral TherapyAntiviral Drug ResistanceAntiviral ResistanceViral EvolutionViral GeneticsViral MutationAntiviral Resistance MutationsDrug Resistance MutationsFlexibilityResistance-associated MutationsResistance-associated Viral VariantsResistance-suppressing MutationsVirus Genotypes
The emergence of drug-resistant variants of HIV continues to be of prime interest in the fields of HIV disease pathogenesis and antiretroviral chemotherapy. Drug resistance is the inevitable conse-quence of incomplete suppression of HIV replication. The rapid replication rate of HIV and its inherent genetic variation lead to the generation of a seemingly limitless number of viral variants that exhibit
104
In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
Jon H. Condra, William A. Schleif, O M Blahy et al. · Nature · 1995 · 979 citations
Ordered accumulation of mutations in HIV protease confers resistance to ritonavir
Akhteruzzaman Molla, Marina Korneyeva, Qing Gao et al. · Nature Medicine · 1996 · 768 citations