Brendan Larder

Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)

Brendan Larder, Sharon D. Kemp · Science · 1989 · 1.2K citations

Resistance to ddI and Sensitivity to AZT Induced by a Mutation in HIV-1 Reverse Transcriptase

M H St Clair, J L Martin, Gareth Tudor‐Williams et al. · Science · 1991 · 681 citations

Immunology, Molecular Biology, Antiviral Drug +17

Potential Mechanism for Sustained Antiretroviral Efficacy of AZT-3TC Combination Therapy

Brendan Larder, Sharon D. Kemp, P. Richard Harrigan · Science · 1995 · 633 citations

Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase.

Margaret Tisdale, Sharon D. Kemp, N. R. Parry et al. · Proceedings of the National Academy of Sciences · 1993 · 607 citations · Full text

Medicine, Human Retrovirus, Antiviral Therapy +15

Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine.

Paul Kellam, Charles A. Boucher, Brendan Larder · Proceedings of the National Academy of Sciences · 1992 · 419 citations · Full text

Codon 215, Genetics, Immunology +18