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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

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Neurodegenerative Diseases, Alzheimer's Disease, Medicine +12

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

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App/ps1 Mice, Neurodegenerative Diseases, Signal Transduction +11

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae et al. · Nature Medicine · 2015 · 2.7K citations · Full text

Inflammation, Anti-inflammatory, Autoimmune Disease +14