Multiple gRNAs-assisted CRISPR/Cas12a-based portable aptasensor enabling glucometer readout for amplification-free and quantitative detection of malathion

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Janice S. Chen, Enbo Ma, Lucas B. Harrington et al. · Science · 2018 · 4.4K citations

Life Sciences, Genetics, Molecular Biology +13

Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy

Parinaz Fozouni, Sungmin Son, María Díaz de León Derby et al. · Cell · 2020 · 1K citations · Full text

Life Sciences, Biotechnology, Molecular Biology +13

Using personal glucose meters and functional DNA sensors to quantify a variety of analytical targets

Yu Xiang, Yi Lu · Nature Chemistry · 2011 · 676 citations · Full text

Engineering, Biomedical Engineering, Biotechnology +16

A CRISPR-Cas autocatalysis-driven feedback amplification network for supersensitive DNA diagnostics

Kai Shi, Shiyi Xie, Renyun Tian et al. · Science Advances · 2021 · 317 citations · Full text

Engineering, Biotechnology, Molecular Biology +16

In vitro selection of aptamers and their applications

Maria C. DeRosa, Amy K. Lin, Prabodhika Mallikaratchy et al. · Nature Reviews Methods Primers · 2023 · 170 citations

Life Sciences, Biotechnology, Molecular Biology +5