Concepedia

Crispr-cas12 Systems

CRISPR-Cas12 Systems is a class of RNA-guided endonuclease systems within the CRISPR-Cas family that uniquely target and cleave double-stranded DNA through a single effector nuclease, Cas12, characterized by its reliance on a T-rich protospacer adjacent motif (PAM) and collateral single-stranded DNA degradation activity upon target recognition.

851

Publications

63.8K

Citations

4.5K

Authors

968

Institutions

Publications per year

2017–2026

849

Parents

Publications

851

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Janice S. Chen, Enbo Ma, Lucas B. Harrington et al. · Science · 2018 · 4.4K citations

, , +13

CRISPR–Cas12-based detection of SARS-CoV-2

James P. Broughton, Xianding Deng, Guixia Yu et al. · Nature Biotechnology · 2020 · 2.8K citations · Full text

, , +8

CRISPR-Cas12a-assisted nucleic acid detection

Shiyuan Li, Qiuxiang Cheng, Jing-Man Wang et al. · Cell Discovery · 2018 · 1.5K citations · Full text

, , +9

Field-deployable viral diagnostics using CRISPR-Cas13

Cameron Myhrvold, Catherine A. Freije, Jonathan S. Gootenberg et al. · Science · 2018 · 1.5K citations · Full text

, , +17

Ultrasensitive and visual detection of SARS-CoV-2 using all-in-one dual CRISPR-Cas12a assay

Xiong Ding, Kun Yin, Ziyue Li et al. · Nature Communications · 2020 · 849 citations · Full text

, , +17

1–5 of 851

Authors

4.5K

  1. CH
    Changjun Hou

    Chongqing University, China

    17 publications · 617 citations

    16

    h-index

  2. DH
    Danqun Huo

    Chongqing University, China

    14 publications · 494 citations

    14

    h-index

  3. BL
    Bingzhi Li

    Nanjing Normal University, China

    10 publications · 293 citations

    11

    h-index

  4. XH
    Xingxu Huang

    ShanghaiTech University, China

    11 publications · 691 citations

    11

    h-index

  5. CL
    Chase L. Beisel

    Helmholtz Institute for RNA-based Infection Research, Germany

    10 publications · 572 citations

    11

    h-index

1–5 of 4.5K

Institutions

968

  1. Chinese Academy of Sciences

    Beijing, China

    32 h-index

    229 publications

    22.3K citations

  2. University of Chinese Academy of Sciences

    Beijing, China

    26 h-index

    136 publications

    14.4K citations

  3. Shanghai Jiao Tong University

    Shanghai, China

    25 h-index

    108 publications

    5.7K citations

  4. Chongqing University

    Chongqing, China

    22 h-index

    148 publications

    5.7K citations

  5. Sun Yat-sen University

    Guangzhou, China

    21 h-index

    80 publications

    4.6K citations

  6. Ministry of Agriculture and Rural Affairs

    Beijing, China

    20 h-index

    109 publications

    5.6K citations

  7. Chinese Academy of Agricultural Sciences

    Beijing, China

    19 h-index

    73 publications

    2.9K citations

  8. Chongqing Medical University

    Chongqing, China

    18 h-index

    136 publications

    6.7K citations

1–8 of 968

Venues

  1. Analytical Chemistry

    76 publications · 6.1K citations

    42

    h-index

  2. Biosensors and Bioelectronics

    61 publications · 3.6K citations

    37

    h-index

  3. Nature Communications

    30 publications · 4.3K citations

    29

    h-index

  4. Sensors and Actuators B Chemical

    50 publications · 2K citations

    26

    h-index

  5. Nucleic Acids Research

    34 publications · 2.2K citations

    25

    h-index

1–5