Rolling-circle-amplification-based DNA-enzyme nanostructure for immobilization and functionalization of enzymes

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

Mengze Lv, Meixia Chen, Rui Zhang et al. · Cell Research · 2020 · 1K citations · Full text

Life Sciences, Immunology, Oncology +17

De novo design of luciferases using deep learning

Hsien‐Wei Yeh, Christoffer Norn, Yakov Kipnis et al. · Nature · 2023 · 451 citations · Full text

Life Sciences, Bioengineering, Molecular Biology +17

Enzyme-powered Janus platelet cell robots for active and targeted drug delivery

Songsong Tang, Fangyu Zhang, Hua Gong et al. · Science Robotics · 2020 · 416 citations

Pharmacy, Biomedical Engineering, Targeted Drug Delivery +1

Aptamer‐PROTAC Conjugates (APCs) for Tumor‐Specific Targeting in Breast Cancer

Shipeng He, Fei Gao, Junhui Ma et al. · Angewandte Chemie International Edition · 2021 · 285 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Double Rolling Circle Amplification Generates Physically Cross-Linked DNA Network for Stem Cell Fishing

Chi Yao, Han Tang, Weijian Wu et al. · Journal of the American Chemical Society · 2020 · 224 citations

Life Sciences, Biotechnology, Cell Biology +13