Alginate-based artificial antigen presenting cells expand functional CD8+ T cells with memory characteristics for adoptive cell therapy

Alginate: Properties and biomedical applications

Kuen Yong Lee, David Mooney · Progress in Polymer Science · 2011 · 7.8K citations

Natural Sciences, Bioengineering, Biomedical Engineering +11

Adoptive T cell therapy using antigen-specific CD8 ⁺ T cell clones for the treatment of patients with metastatic melanoma: <i>In vivo</i> persistence, migration, and antitumor effect of transferred T cells

Cassian Yee, John A. Thompson, D. Byrd et al. · Proceedings of the National Academy of Sciences · 2002 · 1.2K citations

Medicine, Immunology, Oncology +17

Central memory self/tumor-reactive CD8 ⁺ T cells confer superior antitumor immunity compared with effector memory T cells

Christopher A. Klebanoff, Luca Gattinoni, Parizad Torabi‐Parizi et al. · Proceedings of the National Academy of Sciences · 2005 · 972 citations · Full text

Life Sciences, Immunology, Oncology +17

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

Nicole E. Scharping, Dayana B. Rivadeneira, Ashley V. Menk et al. · Nature Immunology · 2021 · 852 citations · Full text

Life Sciences, Cell Biology, Immunology +16

Anti-PD-1 Antibody Therapy Potently Enhances the Eradication of Established Tumors By Gene-Modified T Cells

Liza B. John, Christel Devaud, Connie P.M. Duong et al. · Clinical Cancer Research · 2013 · 700 citations

Life Sciences, Immunology, Oncology +17