Concepedia

Inflation of polygenic risk scores caused by sample overlap and relatedness: Examples of a major risk of bias

Colin A. Ellis, Karen Oliver, Rebekah V. Harris, Ruth Ottman, Ingrid E. Scheffer, Heather C Mefford, Michael P. Epstein, Samuel F. Berkovic, Melanie Bahlo

The American Journal of Human Genetics · 2024 · 12 citations · 11 references

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11

Bias due to participant overlap in two‐sample Mendelian randomization

Stephen Burgess, Neil M Davies, Simon G. Thompson · Genetic Epidemiology · 2016 · 1.8K citations · Full text

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PRSice-2: Polygenic Risk Score software for biobank-scale data

Shing Wan Choi, Paul F. O’Reilly · GigaScience · 2019 · 1.7K citations · Full text

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Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies

Bassel Abou‐Khalil, Pauls Auce, Andreja Avberšek et al. · Nature Communications · 2018 · 513 citations · Full text

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Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions

Akl C. Fahed, Minxian Wang, Julian R. Homburger et al. · Nature Communications · 2020 · 478 citations · Full text

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Polygenic burden in focal and generalized epilepsies

Costin Leu, Remi Stevelink, Alexander C.W. Smith et al. · Brain · 2019 · 151 citations · Full text

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