Concepedia

Polygenic Score Modeling

Polygenic Score Modeling is a computational method that quantifies an individual's genetic predisposition for a trait or disease by aggregating the effects of numerous single nucleotide polymorphisms across the genome, weighted by their effect sizes estimated from genome-wide association studies.

418

Publications

30K

Citations

6.5K

Authors

1.4K

Institutions

Publications per year

2017–2026

367

Variants

Pgs ModelingPolygenic Risk Score Modeling

Parents

Publications

418

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

Amit V. Khera, Mark Chaffin, Krishna G. Aragam et al. · Nature Genetics · 2018 · 3.1K citations

, , +16

PRSice-2: Polygenic Risk Score software for biobank-scale data

Shing Wan Choi, Paul F. O’Reilly · GigaScience · 2019 · 1.7K citations · Full text

, , +16

Power and Predictive Accuracy of Polygenic Risk Scores

Frank Dudbridge · PLoS Genetics · 2013 · 1.6K citations · Full text

, , +17

LDpred2: better, faster, stronger

Florian Privé, Julyan Arbel, Bjarni J. Vilhjálmsson · Bioinformatics · 2020 · 766 citations · Full text

, , +13

The Polygenic Score Catalog as an open database for reproducibility and systematic evaluation

Samuel A. Lambert, Laurent Gil, Simon Jupp et al. · Nature Genetics · 2021 · 744 citations · Full text

, , +11

1–5 of 418

Authors

6.5K

  1. BW
    Benjamin W. Domingue

    Stanford University, United States

    15 publications · 1.2K citations

    14

    h-index

  2. FP
    Florian Privé

    Aarhus University, Denmark

    11 publications · 1.8K citations

    10

    h-index

  3. RP
    Robert Plomin

    King's College London, United Kingdom

    10 publications · 967 citations

    10

    h-index

  4. BJ
    Bjarni J. Vilhjálmsson

    Aarhus University, Denmark

    9 publications · 1.7K citations

    9

    h-index

  5. PM
    Peter M. Visscher

    The University of Queensland, Australia

    9 publications · 1K citations

    9

    h-index

1–5 of 6.5K

Institutions

1.4K

  1. Harvard University

    Cambridge, United States

    35 h-index

    335 publications

    38.9K citations

  2. Massachusetts General Hospital

    Boston, United States

    33 h-index

    228 publications

    36.7K citations

  3. Broad Institute

    Cambridge, United States

    32 h-index

    237 publications

    54.2K citations

  4. King's College London

    London, United Kingdom

    31 h-index

    158 publications

    18.9K citations

  5. Stanford University

    Stanford, United States

    25 h-index

    52 publications

    3.7K citations

  6. Brigham and Women's Hospital

    Boston, United States

    23 h-index

    139 publications

    6.8K citations

  7. University College London

    London, United Kingdom

    22 h-index

    63 publications

    5.2K citations

  8. University of Michigan

    Ann Arbor, United States

    21 h-index

    94 publications

    6.4K citations

1–8 of 1.4K

Venues

  1. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 32 publications · 880 citations

    18

    h-index

  2. Nature Communications

    14 publications · 1.2K citations

    14

    h-index

  3. Translational Psychiatry

    13 publications · 682 citations

    13

    h-index

  4. Scientific Reports

    13 publications · 454 citations

    12

    h-index

  5. The American Journal of Human Genetics

    AJHG · 12 publications · 1.8K citations

    12

    h-index

1–5