Concepedia

Polygenic Risk Scoring

Polygenic Risk Scoring is a computational method in clinical genomics that quantifies an individual’s genetic predisposition to a specific trait or disease by aggregating the effects of numerous single nucleotide polymorphisms across the genome, weighted by their effect sizes derived from genome-wide association studies.

1K

Publications

73.6K

Citations

11.8K

Authors

2.5K

Institutions

Publications per year

2017–2026

907

Variants

Polygenic Risk ScorePrs

Parents

Publications

1K

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

Amit V. Khera, Mark Chaffin, Krishna G. Aragam et al. · Nature Genetics · 2018 · 3.1K citations

, , +16

Polygenic prediction via Bayesian regression and continuous shrinkage priors

Tian Ge, Chia‐Yen Chen, Yang Ni et al. · Nature Communications · 2019 · 2K citations · Full text

, , +17

PRSice-2: Polygenic Risk Score software for biobank-scale data

Shing Wan Choi, Paul F. O’Reilly · GigaScience · 2019 · 1.7K citations · Full text

, , +16

Power and Predictive Accuracy of Polygenic Risk Scores

Frank Dudbridge · PLoS Genetics · 2013 · 1.6K citations · Full text

, , +17

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

Bjarni J. Vilhjálmsson, Jian Yang, Hilary K. Finucane et al. · The American Journal of Human Genetics · 2015 · 1.5K citations · Full text

, , +17

1–5 of 1K

Authors

11.8K

  1. JW
    Jordan W. Smoller

    Massachusetts General Hospital, United States

    31 publications · 6.6K citations

    26

    h-index

  2. AM
    Andrew M. McIntosh

    University of Edinburgh, United Kingdom

    32 publications · 3.6K citations

    25

    h-index

  3. OA
    Ole A. Andreassen

    University of Oslo, Norway

    30 publications · 3.7K citations

    23

    h-index

  4. PK
    Peter Kraft

    Harvard University, United States

    25 publications · 6K citations

    21

    h-index

  5. NR
    Naomi R. Wray

    The University of Queensland, Australia

    24 publications · 3.4K citations

    21

    h-index

1–5 of 11.8K

Institutions

2.5K

  1. Harvard University

    Cambridge, United States

    68 h-index

    707 publications

    141.3K citations

  2. Broad Institute

    Cambridge, United States

    62 h-index

    702 publications

    172.3K citations

  3. Massachusetts General Hospital

    Boston, United States

    61 h-index

    554 publications

    80.9K citations

  4. King's College London

    London, United Kingdom

    47 h-index

    381 publications

    35.7K citations

  5. Brigham and Women's Hospital

    Boston, United States

    45 h-index

    306 publications

    42.7K citations

  6. University of Cambridge

    Cambridge, United Kingdom

    45 h-index

    526 publications

    83.9K citations

  7. University College London

    London, United Kingdom

    42 h-index

    186 publications

    22.8K citations

  8. University of Oxford

    Oxford, United Kingdom

    39 h-index

    175 publications

    18.4K citations

1–8 of 2.5K

Venues

  1. Translational Psychiatry

    51 publications · 2.6K citations

    32

    h-index

  2. Nature Communications

    37 publications · 5.8K citations

    29

    h-index

  3. The American Journal of Human Genetics

    AJHG · 25 publications · 5K citations

    22

    h-index

  4. Scientific Reports

    25 publications · 958 citations

    18

    h-index

  5. Circulation Genomic and Precision Medicine

    19 publications · 994 citations

    18

    h-index

1–5