Concepedia

Polygenic Risk Stratification

Polygenic Risk Stratification is a computational method that categorizes individuals into distinct risk tiers for cardiometabolic diseases based on the aggregate contribution of multiple genetic variants, differentiating it from single-gene risk assessment by integrating polygenic risk scores within a nutrigenomic framework.

507

Publications

32K

Citations

6.2K

Authors

1.5K

Institutions

Publications per year

2017–2026

461

Parents

Publications

507

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

Amit V. Khera, Mark Chaffin, Krishna G. Aragam et al. · Nature Genetics · 2018 · 3.1K citations

, , +16

PRSice: Polygenic Risk Score software

Jack Euesden, Cathryn M. Lewis, Paul F. O’Reilly · Bioinformatics · 2014 · 1.4K citations · Full text

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Gene expression elucidates functional impact of polygenic risk for schizophrenia

Menachem Fromer, Panos Roussos, Solveig K. Sieberts et al. · Nature Neuroscience · 2016 · 1.2K citations · Full text

, , +16

Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer

Paul D.P. Pharoah, Antonis C. Antoniou, Douglas F. Easton et al. · New England Journal of Medicine · 2008 · 623 citations · Full text

, , +17

Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers

Nina Mars, Jukka Koskela, Pietari Ripatti et al. · Nature Medicine · 2020 · 548 citations · Full text

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1–5 of 507

Authors

6.2K

  1. AV
    Amit V. Khera

    Massachusetts General Hospital, United States

    15 publications · 4.7K citations

    15

    h-index

  2. JW
    Jordan W. Smoller

    Massachusetts General Hospital, United States

    15 publications · 1.4K citations

    15

    h-index

  3. PT
    Patrick T. Ellinor

    Massachusetts General Hospital, United States

    12 publications · 3.7K citations

    13

    h-index

  4. AP
    Aarno Palotie

    University of Helsinki, Finland

    13 publications · 1.3K citations

    13

    h-index

  5. PN
    Pradeep Natarajan

    Massachusetts General Hospital, United States

    13 publications · 4.2K citations

    13

    h-index

1–5 of 6.2K

Institutions

1.5K

  1. Harvard University

    Cambridge, United States

    45 h-index

    427 publications

    50K citations

  2. Massachusetts General Hospital

    Boston, United States

    44 h-index

    330 publications

    47K citations

  3. Broad Institute

    Cambridge, United States

    43 h-index

    425 publications

    74.9K citations

  4. Brigham and Women's Hospital

    Boston, United States

    35 h-index

    244 publications

    16.4K citations

  5. University of Cambridge

    Cambridge, United Kingdom

    28 h-index

    402 publications

    51K citations

  6. University College London

    London, United Kingdom

    27 h-index

    96 publications

    6.2K citations

  7. Stanford University

    Stanford, United States

    25 h-index

    145 publications

    6.7K citations

  8. University of Oxford

    Oxford, United Kingdom

    25 h-index

    98 publications

    6K citations

1–8 of 1.5K

Venues

  1. Nature Communications

    18 publications · 1.2K citations

    18

    h-index

  2. Circulation Genomic and Precision Medicine

    19 publications · 815 citations

    17

    h-index

  3. Scientific Reports

    12 publications · 406 citations

    12

    h-index

  4. medRxiv

    Repository · 15 publications · 541 citations

    12

    h-index

  5. The American Journal of Human Genetics

    AJHG · 12 publications · 1.1K citations

    12

    h-index

1–5