Fecal microbiome transplantation alleviates manganese-induced neurotoxicity by altering the composition and function of the gut microbiota via the cGAS–STING/NLRP3 pathway

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

Michael T. Heneka, Markus P. Kummer, Andrea Stutz et al. · Nature · 2012 · 2.8K citations · Full text

App/ps1 Mice, Neurodegenerative Diseases, Signal Transduction +11

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Annett Halle, Veit Hornung, Gabor C. Petzold et al. · Nature Immunology · 2008 · 2.4K citations · Full text

Inflammation, Nalp3 Inflammasome, Innate Immune System +7

NLRP3 inflammasome activation drives tau pathology

Christina Ising, Carmen Venegas, Shuangshuang Zhang et al. · Nature · 2019 · 1.4K citations · Full text

Inflammation, Autoimmune Disease, Disease Mechanism +8

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

Kerstin Berer, Lisa Ann Gerdes, Egle Cekanaviciute et al. · Proceedings of the National Academy of Sciences · 2017 · 901 citations · Full text

Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways

Nicholas W. Bellono, James R. Bayrer, Duncan B. Leitch et al. · Cell · 2017 · 846 citations · Full text

Sensory Neural Pathways, Molecular Neuroscience, Signal Transduction +11