Concepedia

Elucidating PAR1 as a therapeutic target for delayed traumatic brain injury: Unveiling the PPAR-γ/Nrf2/HO-1/GPX4 axis to suppress ferroptosis and alleviate NLRP3 inflammasome activation in rats

Amira A. El-Gazar, Ayman A. Soubh, Dalaal M. Abdallah, Ghada M. Ragab, Hanan S. El‐Abhar

International Immunopharmacology · 2024 · 23 citations · 50 references

DOI

Concepts

References

50

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

José Pedro Friedmann Angeli, Manuela Schneider, Bettina Proneth et al. · Nature Cell Biology · 2014 · 3.6K citations

, , +10

Glutaminolysis and Transferrin Regulate Ferroptosis

Minghui Gao, Prashant Monian, Nosirudeen Quadri et al. · Molecular Cell · 2015 · 2K citations · Full text

, , +12

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

Wan Seok Yang, Brent R. Stockwell · Chemistry & Biology · 2008 · 1.9K citations · Full text

, , +14

Kaempferol Ameliorates Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Ferroptosis by Activating Nrf2/SLC7A11/GPX4 Axis

Yuan Yuan, Yanyu Zhai, Jingjiong Chen et al. · Biomolecules · 2021 · 459 citations · Full text

, , +17

Inhibition of ferroptosis attenuates tissue damage and improves long‐term outcomes after traumatic brain injury in mice

Baoshu Xie, Yi‐Qin Wang, Yong Lin et al. · CNS Neuroscience & Therapeutics · 2018 · 394 citations · Full text

, , +16