PubMed · 2023 · 25 citations · 18 references
PharmacyPharmaceuticsPharmacologyBioavailabilityDrug DeliveryNanoparticle Drug DeliveryDrug EncapsulationNanocarriers For TherapeuticsNanomedicineNanoparticle CharacterizationNanoparticle Delivery SystemsNanoparticle FormulationsControlled Release ProfilesDrug Delivery NanocarriersDynamic Light ScatteringNanoparticle CytotoxicityNanoparticle-mediated Bioavailability EnhancementNanoparticlesPhysicochemical PropertiesRelease Kinetics
studies were conducted to assess the therapeutic efficacy of PCL fortified nano-phytopharmaceuticals in animal models. The results showIased improved bioavailability, targeted tissue distribution, and enhanced therapeutic effects compared to free phytopharmaceuticals. Moreover, the developed nano-phytopharmaceuticals exhibited prolonged circulation time in the bloodstream, enabling improved drug delivery and reduced dosing frequency. This review highlights the promising potential of PCL fortified nano-phytopharmaceuticals as an effective approach for enhancing the therapeutic efficacy of phytopharmaceuticals. The improved stability, bioavailability, sustained release, and targeted delivery achieved through this formulation strategy offer promising opportunities for advancing plant-based therapies. See also the Graphical abstract(Fig. 1).
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Xiaobo Luo, Rongfa Guan, Xiaoqiang Chen et al. · Nanoscale Research Letters · 2014 · 63 citations · Full text