Concepedia

Rational downstream development for adeno-associated virus full/empty capsid separation – A streamlined methodology based on high-throughput screening and mechanistic modeling

William R. Keller, Angela L. Picciano, Kelly G. Wilson, Jin Xu, Harshit Khasa, Michaela Wendeler

Journal of Chromatography A · 2024 · 25 citations · 28 references

DOI

Concepts

References

28

Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield

Sergei Zolotukhin, Barry J. Byrne, Emily Grace Mason et al. · Gene Therapy · 1999 · 1.3K citations

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CD8+ T-cell responses to adeno-associated virus capsid in humans

Federico Mingozzi, Marcela V. Maus, Daniel J. Hui et al. · Nature Medicine · 2007 · 726 citations

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Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors

Sergei Zolotukhin, Mark Potter, Irene Zolotukhin et al. · Methods · 2002 · 577 citations

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Steric mass‐action ion exchange: Displacement profiles and induced salt gradients

Clayton A. Brooks, Steven M. Cramer · AIChE Journal · 1992 · 557 citations

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Production of Recombinant Adeno-associated Virus Vectors Using Suspension HEK293 Cells and Continuous Harvest of Vector From the Culture Media for GMP FIX and FLT1 Clinical Vector

Joshua C. Grieger, Stephen Soltys, R. Jude Samulski · Molecular Therapy · 2015 · 314 citations · Full text

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