Chemical Communications · 2023 · 24 citations · 41 references
Life SciencesCell BiologyMolecular BiologyGene ExpressionMolecular Cell BiologyNucleic Acid BiochemistryDna StabilityG-quadruplex ChemistryNucleic Acid StructureNucleic Acid-protein InteractionsRna StabilityRna StructureG-quadruplex DynamicsG-quadruplex Ligand BindingG-quadruplex RepeatsG-quadruplex StabilityG-quadruplex StructureG-quadruplexesRna Energy Landscapes
Stabilizing DNA/RNA G-quadruplexes (G4s) using small molecules (ligands) has proven an efficient strategy to decipher G4 biology. Quite paradoxically, this search has also highlighted the need for finding molecules able to disrupt G4s to tackle G4-associated cellular dysfunctions. We report here on both qualitative and quantitative investigations that validate the G4-RNA-destabilizing properties of the leading compound PhpC in human cells.
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Adam Siddiqui-Jain, Cory L. Grand, David J. Bearss et al. · Proceedings of the National Academy of Sciences · 2002 · 2.2K citations
Quantitative visualization of DNA G-quadruplex structures in human cells
Giulia Biffi, David Tannahill, John McCafferty et al. · Nature Chemistry · 2013 · 2.2K citations
An RNA G-quadruplex in the 5′ UTR of the NRAS proto-oncogene modulates translation
Sunita Kumari, Anthony Bugaut, J Huppert et al. · Nature Chemical Biology · 2007 · 822 citations · Full text