Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain-specific lifespan and health effects in Caenorhabditis nematodes

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Randy Strong, Z. Dave Sharp, James F. Nelson et al. · Nature · 2009 · 3.7K citations · Full text

Lifespan Extension, Aging, Rapamycin Fed +11

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

Laura A. Herndon, Peter J. Schmeissner, Justyna M. Dudaronek et al. · Nature · 2002 · 1.2K citations

Cell Lineage, Developmental Biology, Aging +9

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

Stacey Robida-Stubbs, Kira Glover-Cutter, Dudley W. Lamming et al. · Cell Metabolism · 2012 · 654 citations · Full text

Lifespan Extension, Signal Transduction, Signaling Pathway +8

Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

Richard A. Miller, David E. Harrison, Clinton M. Astle et al. · Aging Cell · 2013 · 617 citations · Full text

Lifespan Increase, Median Lifespan, Aging +20

Acarbose, 17‐α‐estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

Randy Strong, David B. Allison, Bruce N. Ames et al. · Aging Cell · 2013 · 449 citations · Full text

Maximum Lifespan, Median Lifespan, Aging +22