Concepedia

Itaconate inhibits SYK through alkylation and suppresses inflammation against hvKP induced intestinal dysbiosis

Yangguang Li, Yu Xu, Weizhen Li, Jiayang Li, Wenqi Wu, Jiaqi Kang, Haiyang Jiang, Peizhao Liu, Juanhan Liu, Wenbin Gong,

Cellular and Molecular Life Sciences · 2023 · 18 citations · 42 references

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42

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag et al. · Nature · 2018 · 1.8K citations

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Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

Vicky Lampropoulou, Alexey Sergushichev, Monika Bambousková et al. · Cell Metabolism · 2016 · 1.5K citations · Full text

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Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

Alessandro Michelucci, Thekla Cordes, Jenny Ghelfi et al. · Proceedings of the National Academy of Sciences · 2013 · 1.2K citations · Full text

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Adjunctive Glucocorticoid Therapy in Patients with Septic Shock

Balasubramanian Venkatesh, Simon Finfer, Jeremy Cohen et al. · New England Journal of Medicine · 2018 · 1K citations · Full text

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The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

Alexander Hooftman, Stefano Angiari, Svenja Hester et al. · Cell Metabolism · 2020 · 588 citations · Full text

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