IDH1 mutation impairs antiviral response and potentiates oncolytic virotherapy in glioma

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie, Belinda Phipson, Di Wu et al. · Nucleic Acids Research · 2015 · 40.9K citations · Full text

Genetics, Molecular Biology, Transcriptomics Technology +19

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Lenny Dang, David W. White, Bryson D. Bennett et al. · Nature · 2009 · 4K citations · Full text

Tumor Biology, Cancer-associated Idh1 Mutations, Oncogenic Agent +4

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

María E. Figueroa, Omar Abdel‐Wahab, Chao Lü et al. · Cancer Cell · 2010 · 2.7K citations · Full text

Hematological Malignancy, Somatic Variant, Hypermethylation Phenotype +10

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

Katherine B. Chiappinelli, Pamela L. Strissel, Alexis Desrichard et al. · Cell · 2015 · 1.9K citations · Full text

Chromatin, Epigenetic Change, Dna Methylation +10

( <i>R</i> )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

Julie-Aurore Losman, Ryan Looper, Peppi Koivunen et al. · Science · 2013 · 700 citations · Full text