ChemistrySelect · 2023 · 14 citations · 137 references
PharmacyMedicinal ChemistryPharmacologyDrug DesignDrug DiscoveryStructure-activity RelationshipsLead Compound DesignLead DiscoveryStructure-activity Relationship AnalysisBenzimidazole ChemistryHeterocyclic Medicinal ChemistryMedicinal Chemistry ApplicationsMolecular HybridizationMolecular HybridsPharmacological PotencyPiperidine Chemistry
Abstract Nitrogen‐containing benzimidazole, piperazine, and piperidine are significant pharmacophores in medicinal chemistry and drug development. Many medications, lead compounds, and various reagents have these N‐containing scaffolds. This review concentrated on the development of novel therapeutic agents as well as the broad range of pharmacological actions demonstrated by benzimidazole, piperazine, and piperidine hybrids. The review emphasizes these hybrids′ potential, range, and medical significance. The review also discusses the structural criteria for benzimidazole, piperazine, and piperidine hybrids created by diverse chemists to be physiologically effective against a variety of disorders.
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