Concepedia

Targeting MS4A4A on tumour-associated macrophages restores CD8+ T-cell-mediated antitumour immunity

Yongsheng Li, Zhiyong Shen, Zhen Chai, Yizhi Zhan, Yaowei Zhang, Zhengyu Liu, Yuechen Liu, Zhenkang Li, Mingdao Lin, Zhanqiao Zhang,

Gut · 2023 · 107 citations · 34 references

DOIFull text

Open access

Abstract

Targeting MS4A4A could enhance the ICI efficacy and represent a new anticancer immunotherapy.

References

34

The prognostic landscape of genes and infiltrating immune cells across human cancers

Andrew J. Gentles, Aaron M. Newman, Chih Long Liu et al. · Nature Medicine · 2015 · 3.2K citations · Full text

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T-cell invigoration to tumour burden ratio associated with anti-PD-1 response

Alexander C. Huang, Michael A. Postow, Robert J. Orlowski et al. · Nature · 2017 · 1.6K citations · Full text

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Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer

Lei Zhang, Ziyi Li, Katarzyna M. Skrzypczynska et al. · Cell · 2020 · 1.5K citations · Full text

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CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

Amira Barkal, Rachel Brewer, Maxim Markovic et al. · Nature · 2019 · 1.3K citations

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Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

Olivier De Henau, Matthew Rausch, David A. Winkler et al. · Nature · 2016 · 843 citations

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