Concepedia

Discovery of Ibrutinib-based BTK PROTACs with in vivo anti-inflammatory efficacy by inhibiting NF-κB activation

Junli Huang, Zeli Ma, Zichao Yang, Zengzhu He, Jingna Bao, Xiaopeng Peng, Yao Liu, Ting Chen, Shumin Cai, Jianjun Chen,

European Journal of Medicinal Chemistry · 2023 · 20 citations · 28 references

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28

NF-κB signaling in inflammation

Ting Liu, Lingyun Zhang, Donghyun Joo et al. · Signal Transduction and Targeted Therapy · 2017 · 8.1K citations · Full text

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The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

Lee Honigberg, Ashley M. Smith, Mint Sirisawad et al. · Proceedings of the National Academy of Sciences · 2010 · 1.5K citations · Full text

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Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765

Sarah E. M. Herman, Amber Gordon, Erin Hertlein et al. · Blood · 2011 · 791 citations · Full text

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Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics

Ashley R. Schneekloth, Mathieu Pucheault, Hyun Seop Tae et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 603 citations · Full text

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A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

Minoru Takata, Tomohiro Kurosaki · The Journal of Experimental Medicine · 1996 · 487 citations · Full text

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