Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics

Ashley R. Schneekloth, Mathieu Pucheault, Hyun Seop Tae, +1

Bioorganic & Medicinal Chemistry Letters

Proteomic TechnologyProtein FunctionBiochemistryChemical ProteomicsProtein Folding +10

Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction

Dennis L. Buckley, Inge Van Molle, Peter C. Gareiss, +6

Journal of the American Chemical Society

Small-molecule hydrophobic tagging–induced degradation of HaloTag fusion proteins

Taavi K. Neklesa, Hyun Seop Tae, Ashley R. Schneekloth, +6

Nature Chemical Biology

Protein ChemistryProtein FoldingNatural SciencesMolecular BiologyProteomics +2

Small‐Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α

Dennis L. Buckley, Jeffrey L. Gustafson, Inge Van Molle, +6

Angewandte Chemie International Edition

Pharmacological targeting of the pseudokinase Her3

Ting Xie, Sang Min Lim, Kenneth D. Westover, +12

Nature Chemical Biology

Novel TherapyMedicineTherapeutic EfficacyPharmacotherapyPharmacology +2

Small‐Molecule‐Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging

Jeffrey L. Gustafson, Taavi K. Neklesa, Carly S. Cox, +9

Angewandte Chemie International Edition

Identification of Hydrophobic Tags for the Degradation of Stabilized Proteins

Hyun Seop Tae, Thomas B. Sundberg, Taavi K. Neklesa, +5

ChemBioChem

Development of small molecules targeting the pseudokinase Her3

Sang Min Lim, Ting Xie, Kenneth D. Westover, +8

Bioorganic & Medicinal Chemistry Letters

Protein FunctionProtein ExpressionNatural SciencesChemical BiologyCell Biology +1

Basic peptide-morpholino oligomer conjugate that is very effective in killing bacteria by gene-specific and nonspecific modes

Donna Wesolowski, Hyun Seop Tae, Neeru Gandotra, +3

Proceedings of the National Academy of Sciences

EngineeringBacteriophageNew ConjugateMolecular BiologyDrug Resistance +16

Identification of β-Lapachone Analogs as Novel MALT1 Inhibitors To Treat an Aggressive Subtype of Diffuse Large B-Cell Lymphoma

Sang Min Lim, Yujeong Jeong, Su-Hyun Lee, +6

Journal of Medicinal Chemistry

Drug TargetImmunologyβ-Lapachone AnalogsPeptide ScienceNovel Malt1 Inhibitors +23