Taavi K. Neklesa

Small-molecule hydrophobic tagging–induced degradation of HaloTag fusion proteins

Taavi K. Neklesa, Hyun Seop Tae, Ashley R. Schneekloth et al. · Nature Chemical Biology · 2011 · 423 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance

Jemilat Salami, Shanique Alabi, Ryan R. Willard et al. · Communications Biology · 2018 · 346 citations · Full text

Medicine, Oncology, Pharmacology +16

Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1

Andrew P. Crew, Kanak Raina, Hanqing Dong et al. · Journal of Medicinal Chemistry · 2017 · 251 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +13

ARV-110: An oral androgen receptor PROTAC degrader for prostate cancer.

Taavi K. Neklesa, Lawrence B. Snyder, Ryan R. Willard et al. · Journal of Clinical Oncology · 2019 · 207 citations

Medicine, Oncology, Pharmacology +16

Small‐Molecule‐Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging

Jeffrey L. Gustafson, Taavi K. Neklesa, Carly S. Cox et al. · Angewandte Chemie International Edition · 2015 · 195 citations

Medicine, Oncology, Pharmacology +17