Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations

Medicine, Oncology, Pharmacology +15

Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation

Kathleen M. Sakamoto, Kyung B. Kim, Akiko Kumagai et al. · Proceedings of the National Academy of Sciences · 2001 · 2.5K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters

Paul A. Wender, Dennis J. Mitchell, Kanaka Pattabiraman et al. · Proceedings of the National Academy of Sciences · 2000 · 1.6K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Epoxomicin, a potent and selective proteasome inhibitor, exhibits <i>in vivo</i> antiinflammatory activity

Lihao Meng, Royce Mohan, Benjamin H. Kwok et al. · Proceedings of the National Academy of Sciences · 1999 · 933 citations

Life Sciences, Biochemistry, Molecular Biology +15

Chemical Genetic Control of Protein Levels:  Selective in Vivo Targeted Degradation

John S. Schneekloth, Fabiana N. Fonseca, Michael A. Koldobskiy et al. · Journal of the American Chemical Society · 2004 · 467 citations

Life Sciences, Biochemistry, Molecular Biology +17