Multiplex Genome Engineering Using CRISPR/Cas Systems

Le Cong, F. Ann Ran, David Cox, +8

Science

Single Crispr ArrayEngineeringShort RnasGeneticsSynthetic Biology +10

RNA-Guided Human Genome Engineering via Cas9

Prashant Mali, Luhan Yang, Kevin M. Esvelt, +5

Science

EngineeringGeneticsMolecular BiologyCrispr ComponentsMultiple Grnas +14

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

John A. Zuris, David B. Thompson, Yilai Shu, +7

Nature Biotechnology

Lipid PreparationIn Vivo Gene TherapyBiochemistryNatural SciencesMolecular Biology +8

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

Tongqing Zhou, Ivelin S. Georgiev, Xueling Wu, +15

Science

Phages in nature

Martha R. J. Clokie, Andrew Millard, Andrey V. Letarov, +1

Bacteriophage

Bacteriophage adhering to mucus provide a non–host-derived immunity

Jeremy J. Barr, Rita Auro, Mike Furlan, +10

Proceedings of the National Academy of Sciences

TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors

Vladimir P. Torchilin, Ram Rammohan, Volkmar Weissig, +1

Proceedings of the National Academy of Sciences

Peptide EngineeringImmunologyExtracellular MicrovesiclesImmunotherapyLow Temperature +20

AAV-Mediated Gene Therapy for Research and Therapeutic Purposes

R. Jude Samulski, Nicholas Muzyczka

Annual Review of Virology

Adeno-associated VirusGene TherapiesMolecular VirologyIn Vivo Gene TherapyPathogenesis +13

Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide

Misao Akishiba, Toshihide Takeuchi, Yoshimasa Kawaguchi, +7

Nature Chemistry

Cell-based Drug DeliveryNanomedicineImmunologyAntibody EngineeringMedicine +1

Efficient Intracellular Delivery of Native Proteins

Diego S. D’Astolfo, Romina J. Pagliero, Anita Pras, +6

Cell

Cell-based Drug DeliveryEfficient Intracellular DeliveryProtein EngineeringGene DeliveryProtein Transport +3