Concepedia

Gene Replacement Constructs

A Gene Replacement Construct is a type of transgenic vector designed to substitute an endogenous gene with a modified or exogenous sequence through homologous recombination, distinguished from other gene constructs by its precise integration mechanism and replacement functionality.

626

Publications

59.8K

Citations

2.8K

Authors

795

Institutions

Publications per year

2017–2026

72

Parents

Publications

626

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

Katalin Karikó, Hiromi Muramatsu, Frank A. Welsh et al. · Molecular Therapy · 2008 · 1.9K citations · Full text

, , +17

Lambda replacement vectors carrying polylinker sequences

Anna‐Maria Frischauf, Hans Lehrach, Annemarie Poustka et al. · Journal of Molecular Biology · 1983 · 1.8K citations

, , +7

Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression.

Alexander R. van der Krol, Luis A. J. Mur, Marcel Beld et al. · The Plant Cell · 1990 · 1.2K citations · Full text

, , +17

Versatile suicide vectors which allow direct selection for gene replacement in Gram-negative bacteria

Jürgen Quandt, Michael F. Hynes · Gene · 1993 · 1K citations

, , +7

A Method for Gene Disruption That Allows Repeated Use of URA3 Selection in the Construction of Multiply Disrupted Yeast Strains

Eric Alani, Lei Cao, Nancy Kleckner · Genetics · 1987 · 883 citations

, , +15

1–5 of 626

Authors

2.8K

  1. WW
    William W. Hauswirth

    University of Florida, United States

    11 publications · 898 citations

    11

    h-index

  2. DE
    Dennis E. Ohman

    Virginia Commonwealth University Medical Center, United States

    8 publications · 656 citations

    8

    h-index

  3. MA
    Martin A. Gorovsky

    University of Rochester, United States

    7 publications · 605 citations

    7

    h-index

  4. JF
    Juan F. Martı́n

    Universidad de León, Spain

    6 publications · 398 citations

    6

    h-index

  5. SL
    Sanford L. Boye

    University of Florida, United States

    5 publications · 505 citations

    5

    h-index

1–5 of 2.8K

Institutions

795

  1. Harvard University

    Cambridge, United States

    17 h-index

    67 publications

    10.6K citations

  2. University of Wisconsin–Madison

    Madison, United States

    12 h-index

    30 publications

    4.3K citations

  3. University of Florida

    Gainesville, United States

    12 h-index

    63 publications

    6K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    11 h-index

    48 publications

    4.5K citations

  5. Stanford University

    Stanford, United States

    10 h-index

    46 publications

    6.7K citations

  6. University of Massachusetts Chan Medical School

    Worcester, United States

    9 h-index

    32 publications

    2.5K citations

  7. The University of Osaka

    Osaka, Japan

    9 h-index

    36 publications

    5.1K citations

  8. University College London

    London, United Kingdom

    9 h-index

    20 publications

    1.3K citations

1–8 of 795

Venues

  1. Journal of Bacteriology

    JB · 67 publications · 8.5K citations

    46

    h-index

  2. Applied and Environmental Microbiology

    AEM · 37 publications · 3.1K citations

    28

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 26 publications · 4.7K citations

    25

    h-index

  4. Molecular Microbiology

    28 publications · 2.4K citations

    24

    h-index

  5. Molecular and Cellular Biology

    MCB · 29 publications · 2.3K citations

    23

    h-index

1–5