Concepedia

Myeloid-derived itaconate suppresses cytotoxic CD8+ T cells and promotes tumour growth

Hongyun Zhao, Da Teng, Lifeng Yang, Xincheng Xu, Jiajia Chen, Teng‐Jia Jiang, Austin Y. Feng, Yaqing Zhang, Dennie T. Frederick, Lei Gu,

Nature Metabolism · 2022 · 161 citations · 33 references

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33

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag et al. · Nature · 2018 · 1.8K citations

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Arginase I Production in the Tumor Microenvironment by Mature Myeloid Cells Inhibits T-Cell Receptor Expression and Antigen-Specific T-Cell Responses

Paulo C. Rodrı́guez, David Quiceno, Jovanny Zabaleta et al. · Cancer Research · 2004 · 1.2K citations · Full text

, , +17

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

Alessandro Michelucci, Thekla Cordes, Jenny Ghelfi et al. · Proceedings of the National Academy of Sciences · 2013 · 1.2K citations · Full text

, , +16

Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma

David Liu, Bastian Schilling, Derek Liu et al. · Nature Medicine · 2019 · 1.1K citations · Full text

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Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients

Thomas Condamine, George A. Dominguez, Je‐In Youn et al. · Science Immunology · 2016 · 799 citations

, , +17