Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

Meredith A. Collins, Filip Bednar, Yaqing Zhang, +7

Journal of Clinical Investigation

Kras MutationsTumor BiologyOncogenic KrasOncologyDevelopmental Biology +10

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer

Christopher J. Halbrook, Corbin Pontious, Ilya Kovalenko, +20

Cell Metabolism

OncologyPancreatic CancerMedicineAnti-cancer AgentPharmacology +2

Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer

Yaqing Zhang, Ashley Velez-Delgado, Esha Mathew, +7

Gut

Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer

Nina G. Steele, Giulia Biffi, Samantha B. Kemp, +33

Clinical Cancer Research

Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance

Yaqing Zhang, Wei Yan, Meredith A. Collins, +7

Cancer Research

ImmunologyCell DeathIl-6 EmergesCancer BiologyTumor Biology +15

Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis

Yaqing Zhang, John P. Morris, Wei Yan, +7

Cancer Research

Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB–Mediated Production of CXCL1

Samantha B. Kemp, Eileen S. Carpenter, Nina G. Steele, +15

Cancer Research

Metastatic Pancreatic Cancer Is Dependent on Oncogenic Kras in Mice

Meredith A. Collins, Jean‐Christophe Brisset, Yaqing Zhang, +6

PLoS ONE

Oncogenic KrasOncologyPancreatic CancerOncogenic AgentMedicine +10

Myeloid-derived itaconate suppresses cytotoxic CD8+ T cells and promotes tumour growth

Hongyun Zhao, Da Teng, Lifeng Yang, +16

Nature Metabolism

Hematological MalignancyTumour GrowthImmunologyMyeloid-derived Itaconate SuppressesCd8+ T Cells +6

Phenformin Inhibits Myeloid-Derived Suppressor Cells and Enhances the Anti-Tumor Activity of PD-1 Blockade in Melanoma

Sun Hye Kim, Man Li, Sebastian Trousil, +4

Journal of Investigative Dermatology

Pd-1 BlockadeMedicineMelanomaImmunologyImmune Checkpoint Inhibitor +6