In-depth characterisation of a cohort of individuals with missense and loss-of-function variants disrupting <i>FOXP2</i>

Abstract

Although we identify an increased prevalence of conditions like anxiety, depression and sleep disturbance, we confirm that the consequences of <i>FOXP2</i> dysfunction remain relatively specific to speech disorder, as compared with other recently identified monogenic conditions associated with CAS. Thus, our findings reinforce that <i>FOXP2</i> provides a valuable entry point for examining the neurobiological bases of speech disorder.