Limited Proteolysis–Mass Spectrometry to Identify Metabolite–Protein Interactions

Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips

Juri Rappsilber, Matthias Mann, Yasushi Ishihama · Nature Protocols · 2007 · 4.9K citations

Life Sciences, Biochemistry, Biotechnology +10

Dose-Response Analysis Using R

Christian Ritz, Florent Baty, J. C. Streibig et al. · PLoS ONE · 2015 · 3.7K citations · Full text

Public Health, Biostatistics, Dose-response Modeling +12

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

Bryson D. Bennett, Elizabeth Kimball, Melissa Gao et al. · Nature Chemical Biology · 2009 · 1.9K citations · Full text

Life Sciences, Biochemistry, Microbiology +16

Extending the Limits of Quantitative Proteome Profiling with Data-Independent Acquisition and Application to Acetaminophen-Treated Three-Dimensional Liver Microtissues

Roland Bruderer, Oliver M. Bernhardt, Tejas Gandhi et al. · Molecular & Cellular Proteomics · 2015 · 1.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Tracking cancer drugs in living cells by thermal profiling of the proteome

Mikhail M. Savitski, Friedrich Reinhard, Holger Franken et al. · Science · 2014 · 1.2K citations

Pharmacy, Biochemistry, Oncology +17