Concepedia

Thymidine rescues ATR kinase inhibitor-induced deoxyuridine contamination in genomic DNA, cell death, and interferon-α/β expression

Norie Sugitani, Frank P. Vendetti, Andrew J. Cipriano, Pinakin Pandya, Joshua J. Deppas, Tatiana N. Moiseeva, Sandra Schamus-Haynes, Yiyang Wang, Drake Palmer, Hatice U. Osmanbeyoglu,

Cell Reports · 2022 · 25 citations · 53 references

DOIFull text

Open access

Concepts

Abstract

T cell-dependent anti-tumor responses in mouse models. We conclude that ATR is essential to limit dU contamination in genomic DNA and IFN-α/β expression.

References

53

Fast gapped-read alignment with Bowtie 2

Ben Langmead, Steven L. Salzberg · Nature Methods · 2012 · 61.1K citations

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Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Lee Zou, Stephen J. Elledge · Science · 2003 · 2.7K citations

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Chk1 is an essential kinase that is regulated by Atr and required for the G<sub>2</sub>/M DNA damage checkpoint

Qinghua Liu, Saritha Guntuku, Xian-Shu Cui et al. · Genes & Development · 2000 · 1.6K citations · Full text

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ATR and ATRIP: Partners in Checkpoint Signaling

David Cortez, Saritha Guntuku, Jun Qin et al. · Science · 2001 · 968 citations

, , +17

IL-7 is critical for homeostatic proliferation and survival of naïve T cells

Joyce T. Tan, Eric Dudl, Eric M. Leroy et al. · Proceedings of the National Academy of Sciences · 2001 · 955 citations · Full text

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