Proceedings of the National Academy of Sciences · 2001 · 955 citations · 52 references
Life SciencesCell BiologyImmunologyAdaptive ImmunityCellular ImmunologyImmunoregulationCell-mediated ImmunityCytokine BiologyImmune HomeostasisImmune RegulationT Cell ActivationT Cell BiologyInterleukin-7 SignalingNaive T Cell HomeostasisNaive T CellsNaive T-cell ActivationPeripheral Immune HomeostasisT-cell Homeostatic Proliferation
In T cell-deficient conditions, naive T cells undergo spontaneous "homeostatic" proliferation in response to contact with self-MHC/peptide ligands. With the aid of an in vitro system, we show here that homeostatic proliferation is also cytokine-dependent. The cytokines IL-4, IL-7, and IL-15 enhanced homeostatic proliferation of naive T cells in vitro. Of these cytokines, only IL-7 was found to be critical; thus, naive T cells underwent homeostatic proliferation in IL-4(-) and IL-15(-) hosts but proliferated minimally in IL-7(-) hosts. In addition to homeostatic proliferation, the prolonged survival of naive T cells requires IL-7. Thus, naïve T cells disappeared gradually over a 1-month period upon adoptive transfer into IL-7(-) hosts. These findings indicate that naive T cells depend on IL-7 for survival and homeostatic proliferation.
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T cell receptor antagonist peptides induce positive selection
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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
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