Concepedia

Gemini lipid nanoparticle (GLNP)-mediated oral delivery of TNF-α siRNA mitigates gut inflammation <i>via</i> inhibiting the differentiation of CD4<sup>+</sup> T cells

Priyanka Verma, Amit Arora, Kajal Rana, Devashish Mehta, Raunak Kar, Vikas Verma, Chittur V. Srikanth, Veena S. Patil, Avinash Bajaj

Nanoscale · 2022 · 12 citations · 25 references

DOI

Concepts

Abstract

cells. Therefore, this study highlights the potential of GLNPs derived from lithocholic acid-derived gemini cationic lipids for the development of next-generation nucleic acid delivery vehicles.

References

25

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells

Eva V. Acosta Rodríguez, Giorgio Napolitani, Antonio Lanzavecchia et al. · Nature Immunology · 2007 · 1.8K citations

, , +16

Regulation of inflammatory responses by IL-17F

Xuexian O. Yang, Seon Hee Chang, Heon Park et al. · The Journal of Experimental Medicine · 2008 · 737 citations · Full text

, , +17

Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines

David S. Wilson, Guillaume Dalmasso, Lixin Wang et al. · Nature Materials · 2010 · 715 citations · Full text

, , +16

Critical role of IL-17 receptor signaling in acute TNBS-induced colitis

Zili Zhang, Mingquan Zheng, J. Bindas et al. · Inflammatory Bowel Diseases · 2006 · 459 citations

, , +17

Advances in gene delivery through molecular design of cationic lipids

Santanu Bhattacharya, Avinash Bajaj · Chemical Communications · 2009 · 266 citations

, , +17