Regulatory Effects of <i>Lycium barbarum</i> Extract and Isolated Scopoletin on Atopic Dermatitis‐Like Skin Inflammation

Abstract

<i>Lycium barbarum</i> and scopoletin are widely used in oriental Eastern medicine and are often consumed as teas. In this study, proinflammatory cytokines expressed in human keratinocytes (HaCaT) were induced by skin diseases caused by 2,4-dinitrochlorobenzene (DNCB) and tumor necrosis factor alpha (TNF-<i>α</i>)/interferon gamma (IFN-<i>γ</i>). The inhibitory activity of <i>L. barbarum</i> EtOH extract (LBE) and scopoletin on proinflammatory cytokines and chemokines was investigated. In the DNCB-induced animal model, oral administration of LBE inhibited skin lesions and proinflammatory cytokines and chemokines and showed inhibitory effects <i>in vitro</i>. Additionally, as a result of examining the efficacy of scopoletin isolated from <i>L. barbarum</i>, scopoletin in HaCaT cells showed inhibitory effects on proinflammatory cytokines and chemokines. It shows promise in the treatment of chronic skin diseases.