Tauroursodeoxycholic acid functions as a critical effector mediating insulin sensitization of metformin in obese mice

Role of AMP-activated protein kinase in mechanism of metformin action

Gaochao Zhou, Robert P. Myers, Ying Li et al. · Journal of Clinical Investigation · 2001 · 5.3K citations

Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

Fredrik Bäckhed, Jill K. Manchester, Clay F. Semenkovich et al. · Proceedings of the National Academy of Sciences · 2007 · 2.5K citations · Full text

Nutrition, Host-microbe Interactions, Ampk Activity +20

Human gut microbes impact host serum metabolome and insulin sensitivity

Helle Pedersen, Valborg Guðmundsdóttir, Henrik Bjørn Nielsen et al. · Nature · 2016 · 2.1K citations · Full text

Obesity, Dysbiosis, Host-microbe Interactions +14

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

Falk Hildebrand, Trine Nielsen, Gwen Falony et al. · Nature · 2015 · 2K citations · Full text

Diabetes Management, Dysbiosis, Treatment Signatures +13

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

Hubert Plovier, Amandine Everard, Céline Druart et al. · Nature Medicine · 2016 · 2K citations · Full text

Metabolic Syndrome, Energy Metabolism, Biochemistry +9