Single domain antibodies targeting pathological tau protein: Influence of four IgG subclasses on efficacy and toxicity

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

Hirohide Asai, Seiko Ikezu, Satoshi Tsunoda et al. · Nature Neuroscience · 2015 · 1.6K citations · Full text

Alzheimer's Disease, Medicine, Immunology +7

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

Jada Lewis, Eileen McGowan, Julia M. Rockwood et al. · Nature Genetics · 2000 · 1.3K citations

Neurodegenerative Diseases, Alzheimer's Disease, Neurofibrillary Tangles +9

Divergent Immunoglobulin G Subclass Activity Through Selective Fc Receptor Binding

Falk Nimmerjahn, Jeffrey V. Ravetch · Science · 2005 · 1K citations

Immunology, Immunodominance, Immunologic Mechanism +16

The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans

Jerrah K. Holth, Sarah K. Fritschi, Chanung Wang et al. · Science · 2019 · 749 citations · Full text

FcγRIV: A Novel FcR with Distinct IgG Subclass Specificity

Falk Nimmerjahn, Pierre Bruhns, Ken Horiuchi et al. · Immunity · 2005 · 648 citations · Full text

Novel Fcr, Engineering, Computational Genomics +3