Depletion of microglia and inhibition of exosome synthesis halt tau propagation

Hirohide Asai, Seiko Ikezu, Satoshi Tsunoda, +7

Nature Neuroscience

Alzheimer's DiseaseMedicineImmunologyCell DeathDegenerative Pathology +5

Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons

Zhi Ruan, Dhruba Pathak, Srinidhi Venkatesan Kalavai, +14

Brain

Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

Kevin A. Clayton, Jean-Christophe Delpech, Shawn Herron, +6

Molecular Neurodegeneration

Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer’s Disease Patients: A Pilot Study

Satoshi Muraoka, Mark P. Jedrychowski, Kiran Yanamandra, +3

Cells

Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues

Satoshi Muraoka, Annina M. DeLeo, Manveen K. Sethi, +16

Alzheimer s & Dementia

P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice

Zhi Ruan, Jean-Christophe Delpech, Srinidhi Venkatesan Kalavai, +4

Molecular Neurodegeneration

Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease

Zhuoran Yin, Shawn Herron, Sebastian Silveira, +20

Nature Neuroscience

InflammationNeurodegenerative DiseasesAlzheimer's DiseaseMedicineImmunology +13

miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction

Maya E. Woodbury, Robert W. Freilich, Chang Cheng, +5

Journal of Neuroscience

Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities

Seiko Ikezu, Hana Yeh, Jean-Christophe Delpech, +19

Molecular Psychiatry

ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids

Yang You, Zhengrong Zhang, Nadia Sultana, +7

Science Advances