Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons

Zhi Ruan, Dhruba Pathak, Srinidhi Venkatesan Kalavai, +14

Brain

Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues

Satoshi Muraoka, Annina M. DeLeo, Manveen K. Sethi, +16

Alzheimer s & Dementia

P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice

Zhi Ruan, Jean-Christophe Delpech, Srinidhi Venkatesan Kalavai, +4

Molecular Neurodegeneration

Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities

Seiko Ikezu, Hana Yeh, Jean-Christophe Delpech, +19

Molecular Psychiatry

Weight at birth and adolescence and premenopausal breast cancer risk in a low-risk population

Maureen Sanderson, Xiao‐Ou Shu, Fan Jin, +4

British Journal of Cancer

ObesityBreast OncologyCancer RiskCancer EpidemiologyLow-risk Population +8

Dysregulation of neurotrophic and inflammatory systems accompanied by decreased CREB signaling in ischemic rat retina

Xian Jun Guo, Xue Tian, Zhi Ruan, +5

Experimental Eye Research

Ischemic Rat RetinaGanglion CellPhotoreceptor CellSignal TransductionInflammatory Systems +8

MIF promotes neurodegeneration and cell death via its nuclease activity following traumatic brain injury

Zhi Ruan, Qing Lu, Jennifer E. Wang, +8

Cellular and Molecular Life Sciences

Traumatic Brain InjuryApoptosisCell DeathGliomaSocial Sciences +14

Extracellular vesicles drive tau spreading in Alzheimer’s disease

Zhi Ruan

Neural Regeneration Research

Molecular BiologyNeurochemical BiomarkersSynaptic SignalingTau ProteinSocial Sciences +21

Functional genome-wide short hairpin RNA library screening identifies key molecules for extracellular vesicle secretion from microglia

Zhi Ruan, Kayo Takamatsu-Yukawa, Yuzhi Wang, +5

Cell Reports

Long-Term Vision and Non-Vision Dominant Behavioral Deficits in the 2-VO Rats Are Accompanied by Time and Regional Glial Activation in the White Matter

Xue Tian, Xian Jun Guo, Zhi Ruan, +3

PLoS ONE

NeuropsychologyBrain FunctionWhite MatterSocial SciencesPermanent Occlusion +18