Metformin prevents morphine-induced apoptosis in rats with diabetic neuropathy: a possible mechanism for attenuating morphine tolerance

Oxidative Injury and Apoptosis of Dorsal Root Ganglion Neurons in Chronic Experimental Diabetic Neuropathy

Ann M. Schmeichel, James D. Schmelzer, Phillip A. Low · Diabetes · 2003 · 365 citations · Full text

Life Sciences, Neurobiology, Neuroscience +16

Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia

Gregory Corder, Vivianne L. Tawfik, Dong Wang et al. · Nature Medicine · 2017 · 348 citations

Nursing, Neuroscience, Pharmacology +12

Glia as the “bad guys”: Implications for improving clinical pain control and the clinical utility of opioids

Linda R. Watkins, Mark R. Hutchinson, Annemarie Ledeboer et al. · Brain Behavior and Immunity · 2006 · 327 citations · Full text

Nursing, Pharmacology, Pharmacotherapy +16

Neuronal Apoptosis Associated with Morphine Tolerance: Evidence for an Opioid-Induced Neurotoxic Mechanism

Jianren Mao, Backil Sung, Ru‐Rong Ji et al. · Journal of Neuroscience · 2002 · 320 citations · Full text

Medicine, Neuroscience, Pharmacology +17

Attenuation of Morphine Tolerance, Withdrawal-Induced Hyperalgesia, and Associated Spinal Inflammatory Immune Responses by Propentofylline in Rats

Raghavendra Vasudeva, Flobert Tanga, Joyce A. DeLeo · Neuropsychopharmacology · 2003 · 259 citations

Medicine, Neuroscience, Pharmacology +16