Mark R. Hutchinson

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

Mark R. Hutchinson, Yingning Zhang, Mitesh Shridhar et al. · Brain Behavior and Immunity · 2009 · 562 citations

Opioid Epidemic, Molecular Pharmacology, Health Sciences +12

Morphine activates neuroinflammation in a manner parallel to endotoxin

Xiaohui Wang, Lisa C. Loram, Khara M. Ramos et al. · Proceedings of the National Academy of Sciences · 2012 · 503 citations · Full text

Non‐stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll‐like receptor 4 (TLR4)

Mark R. Hutchinson, Yingning Zhang, Kimberley Brown et al. · European Journal of Neuroscience · 2008 · 389 citations · Full text

Pain Therapy, Pain Disorders, Pain Medicine +22

Opioid Activation of Toll-Like Receptor 4 Contributes to Drug Reinforcement

Mark R. Hutchinson, Alexis L. Northcutt, Takato Hiranita et al. · Journal of Neuroscience · 2012 · 343 citations · Full text

Pain Medicine, Morphine-tlr4/md2 Binding, Immunology +19

Glia as the “bad guys”: Implications for improving clinical pain control and the clinical utility of opioids

Linda R. Watkins, Mark R. Hutchinson, Annemarie Ledeboer et al. · Brain Behavior and Immunity · 2006 · 323 citations · Full text

Pain Therapy, Pain Research, Pain Disorders +14